July 2008 - Lab Scientists Awarded ICTR Grants
Both Dr. Cathy Gallagher and Dr. Michele Ries were recently awarded pilot grants through the University of Wisconsin’s Institute for Clinical and Translational Research. Dr. Gallagher’s project will focus on MRI measurements of basal ganglia perfusion and connectivity in Parkinson disease. Dr. Ries’ project will use functional MRI to examine alterations in brain physiology relating to impaired awareness of memory deficit in people with mild cognitive impairment and Alzheimer’s disease.
July 2008 - Wisconsin Researchers to Share Results with International Colleagues
Researchers from the WCMP were in Chicago for the Alzheimer's Association International Conference on Alzheimer's Disease, July 26-31, 2008. The program's research was featured in several oral and poster presentations.
Posters Presented:
Authors: Khosropour, C, Dowling, M Wharton, W, Edwards, D, Carlsson, C, Asthana, S, Gleason, C
Title: Influence of Vascular Risk Factors on Cognitive Performance in Community-Dwelling African Americans
Authors: Bendlin B, Thiel B, Jabbar B, Kastman K, Fitzgerald M, Gliori G, Asthana S, Sager M, Alexander A, Lazar M, Johnson S
Title: Parental family history is related to microstructural brain changes in presymptomatic middle aged and older adults. Alzheimer’s Association International Conference on prevention of Dementia
Authors: Carlsson, C, Barnet J, Blazel, H, Puglielli L, Atwood, C, Gleason, C, Johnson, S, Sager, M, Asthana, S
Title: Relationship of Atherogenic Lipid Profiles and Gender with CSF Biomarkers in Middle-Aged Adults at Risk for Alzheimer’s Disease
Authors: Carlsson, C, Dowling, M, Asthana, S, Gleason, C, Johnson, S, La Rue, A, Hermann, B, Sager, M.
Title: Increased Duration of Statin Use Is Associated with Better Cognitive Performance in Middle-Aged Adults at Risk for AD: The Wisconsin Registry for Alzheimer’s Prevention (WRAP)
Authors: Dowling, M, Hermann, B, LaRue, A, Sager, M
Title: An Examination Of The Latent Structure Of The Neuropsychological Test Battery Of The Wisconsin Registry For Alzheimer’S Prevention (WRAP)
Authors: Fitzgerald, M, Bendlin, B, Xu, G, McLaren, D, Kastman, E, Newman, L, Sager, M, Asthana, S, Johnson, S
Title: Regional Gray Matter Brain Volume Differences in Individuals with a Maternal vs. Paternal Family History of Alzheimer’s Disease
Authors: Gleason C, Dowling N, Wharton W, Khosropour C, Carlsson C, Asthana S
Title: Cognitive Benefits of Hormone Therapy Use in Women Matched for Cardiovascular Risk Factors. Accepted for presentation at International Congress on Alzheimer's Disease
Authors: Blazel H, Gilbertson L, Asthana S, Sager M, Carlsson C
Title: Lumbar Puncture Procedures Are Not a Barrier to Recruitment Into Clinical Trials For Alzheimer's Disease Prevention
Authors: Kastman E, Bendlin B, Xu G, Ries M, McLaren D, Fitzgerald M, Jabbar B, Kosmatka K, Johnson S
Title: Rate Of Whole Brain Volume Decline In A Cohort Of Cognitively Normal Participants With Family History Of Alzheimer’S Disease: A Longitudinal Study
Authors: La Rue, A, Hermann, B, Dowling, M, Wright, N, Sager, M
Title: Interactive effects of family history of AD and childhood learning difficulties on midlife memory performance
Authors: McLaren D, Ries M, Bendlin B, Kastman E, Kosmatka K, Xu G, Jabbar B, Newman L, Fitzgerald M, Johnson S
Title: Memory Formation In Middle-aged Adults: Dynamics Of The Bold Signal Across Repetitions
Authors: Porayette P, Gallego M, Kaltcheva M, Bowen R, Meethal S, Atwood C
Title: Differential Processing of Amyloid-β Precursor Protein Directs the Proliferation and Neuronal Differentiation of Human Embryonic Stem Cells
Authors: Ries M, McLaren, D, Fitzgerald, M, Asthana S, Johnson S
Title: Attenuated Functional Connectivity Associated with Impaired Awareness of Deficit in Amnestic Mild Cognitive Impairment. Alzheimer’s Association International Conference on prevention of Dementia
Authors: Meethal S, Chan H, Ginsburg E, Wilson A, Bowen R, Vonderhaar B, Atwood C
Title: Identification of a Negative Feedback Loop in the Brain for the Regulation of Neurosteroid Synthesis: Implications for Alzheimer’s Disease
Authors: Meethal S, Ockuly J, Porayette P, Gallego M, Haworth R, Bowen R, Atwood C
Title: Gonadotropin-Releasing Hormone Signaling in the Aging Brain: A Recapitulation of its Role in Embryogenesis and its Implications for Alzheimer’s Disease
Authors: Wharton W, Gleason C, Brinton E, Cedars M, Lobo R, Manson J, Merriam G, Miller V, Taylor H, Lobo R, Santoro N, Harman S, Asthana S
Title: Baseline Cognitive and Demographic Characteristics of Women Enrolled in the KEEPS (Kronos Early Estrogen Prevention Study) Cognitive and Affective Study
Authors: Xu G, Fitzgerald M, Sager M, Asthana S, Johnson S
Title: Early onset of Alzheimer’s disease study with MR-ASL, FDG-PET, PIB-PET and O15-PET - a multiple-modal neuroimage approach
Authors: Xu G, Mclaren D, Fitzgerald M, Ries M, Rowley H, Sager M, Asthana S, Johnson S
Title: The influence of Alzheimer’s Disease Family History and Apolipoprotein E ε4 on task dependent posterior cingulate activation
Authors: Xu, G, Dowling M, Fitzgerald, M, Kastman E, M, Sager, M, Asthana, S, Johnson, S.
Title: fMRI activation in medial temporal lobe correlates with monthly decline rate of memory function in mild cognitive impairment patients
March 2008 - Tomorrow's Leader in Alzheimer's Disease Grant awarded to Dr. Sterling Johnson
Dr. Sterling Johnson has been honored by three leading Alzheimer's associations as one of 3 recipients of the Tomorrow's Leader Award for 2008. The award from the Alzheimer's Association, Cure Alzheimer Fund and the Lou Ruvo Brain Institute will help support our research on cognitive disorders of memory and self-awareness.
Research Conference Appearances
Exciting research findings from the Wisconsin Comprehensive Memory Program are routinely presented at research conferences across the globe. Such conference appearances allow WCMP researchers and staff to share in the knowledge and collaborate in the progress being made globally in this field, and to demonstrate our vision and commitment to the future of Alzheimer's research. To have one of our researchers come and speak to your group, just contact us!
Resources:
WCMP Presentation/Speaker Requests
Wisconsin Comprehensive Memory Program staff is available to speak to your group of caregivers, professionals, or other community members about several topics including the advances being made in the field of memory research across the globe and right here in Madison. To discuss this opportunity, please contact Tamara Markgraf at (608) 256-1901, ext. 12923 or by email at: tsm@medicine.wisc.edu.
University of Wisconsin Memory Assessment Clinic: part of the Geriatrics Clinic at University Station
The Memory Assessment Clinic provides assessments of persons who are experiencing a decline in memory and cognitive function. The appointment lasts approximately two hours. During the first hour, the patient undergoes neuropsychological testing which helps to define the problem areas. During that time, a social worker meets with the family to obtain a more extensive history and further background information. This is a good time to discuss concerns, possible options, and ask questions and obtain answers.
After that time, the neuropsychologist, social worker and doctor meet briefly to discuss patient assessment. When the physician meets with the patient and family, they already have the preliminary results of the neuropsychological testing, a synopsis of the history and concerns, and background medical information. The physician usually performs a brief neurological examination as part of the evaluation. They may request that a scan or blood work be done to seek the cause of the memory decline. If that is the case, the patient is scheduled for a return appointment shortly after the additional information is collected. The team works with the family and patient to plan for the future as well as for the present.
For questions about the UW Memory Assessment Clinic or to schedule an appointment, call the clinic at (608) 263-7740.
UW Madison Campus Links
Institute on Aging
The Laboratory of Endocrinology, Aging, and Disease
Neuropsychology Neuroimaging Lab
Neuroscience Training Program
Wisconsin Alzheimer's Institute
VA Hospital Madison
Research
Alzheimer's Disease Centers Directory
Alzheimer Research Forum
Dana Brain Web
Associations
South Central Wisconsin Chapter of the Alzheimer's Association
The Alliance for Aging Research
Alzheimer's Association
Benjamin B. Green-Field Library & Resource
Center
Alzheimer's Disease Education And Referral (ADEAR)
American Academy of Neurology
American Association for Geriatric Psychiatry
American Association of Retired Persons
American Medical Association
American Geriatrics Society
American Psychiatric Association
American Society on Aging
National Institute on Aging
National Institutes of Health
National Parkinson's Foundation
Society for Neuroscience
Other
Alzheimer Europe
Dementia Web
Elder Care
GeroWeb
Timeslips
Memory on the Mind - To the Best of Our Knowledge (National Public Radio), November 11, 2001 (Requires free Real Audio player).
